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Orlistat
10%
Max weight loss
4.58/5
Patient rating
MHRA approved
Regulation
OTC Oral Capsule

Orlistat

Clinically proven fat-blocking tablet

4.58/5 · 1751+ verified reviews

Orlistat is a fat-blocking weight loss tablet that works by preventing your body from absorbing about one-third of the fat you eat. It is the only weight loss medication available over the counter in the UK (at 60mg) and by prescription at 120mg.

New to Orlistat? You'll start on 60mg
£39.00
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Available without prescription – ideal starting point for weight management

Benefits:

~10% average body weight loss
Significant weight reduction
Clinically proven weight loss
Free discreet delivery to Manchester

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What is Orlistat?

Orlistat is a prescription medication formulated for weight loss and long-term weight management.

Active ingredient

Orlistat works by inhibiting pancreatic and gastric lipase enzymes, which are needed to break down dietary fat.

How it works

It blocks absorption of approximately one-third of dietary fat. The unabsorbed fat is passed through the bowel naturally.

Administration

Take one capsule with each main meal containing fat (up to 3 times daily). Can be taken up to 1 hour after eating.

Suitability

60mg available OTC without prescription. 120mg available with prescription. Works best alongside a low-fat, calorie-controlled diet.

Effectiveness

Patients typically lose 5-10% of body weight over 12 months when used alongside a reduced-fat diet and exercise.

Side effects

Oily/fatty stools, frequent bowel movements, and oily spotting on underwear. Significantly reduced by following a low-fat diet.

Orlistat can help you manage weight effectively and achieve significant weight loss alongside a diet and exercise programme.

Side effects & safety

Common side effects include oily or fatty stools, oily spotting on underwear, frequent or urgent bowel movements, and oily discharge. These are significantly reduced by following a strict low-fat diet.

Our clinical team is available to support you throughout your treatment. Contact us anytime if you experience any concerns.

8+ Orlistat reviews

Verified Orlistat patient reviews from our customers

19 May 2026

"I absolutely love this product. I have been using 2.5mg as a maintenance dose and have managed to control my weight without any side effects, and can still eat well balanced meals. The pharmacy is very efficient, friendly and helpful — I would not purchase from anywhere else."

Ann-Marie
Orlistat · Verified purchase · Judge.me
23 Apr 2026

"So far I'm really impressed by my results, it's crazy because I'm not snacking like how I used to, and I can see my face slimming down already and it's only been two and a half weeks... Can't wait to give my feedback in 5 months time, thank you Cured Pharmacy."

Sacha W.
Orlistat · Verified purchase · Judge.me
18 Mar 2026

"I used before and my experience was very good, I lost 36kg from 143kg after 6 months. I started again, my target is 90kg."

Florin R.
Orlistat · Verified purchase · Judge.me
⭐ See all verified reviews

Real Results

Real Orlistat results from real people

Sophie Before Before
Sophie After After
Sophie Lost 4st (25kg)
25kg
Lost
12
Months
Mounjaro
Treatment
Leanne Before Before
Leanne After After
Leanne Lost 6st 2lb (39kg)
39kg
Lost
12
Months
Wegovy
Treatment
Ellie Before Before
Ellie After After
Ellie Lost 56lb (25kg)
25kg
Lost
3
Months
Mounjaro
Treatment
Check if you're eligible

Orlistat sources and references

Here are some additional resources to help you learn more about Orlistat, how it works, and clinical studies related to the drug.

Frequently asked questions about Orlistat

Answered by our experienced medical team.

Tarun Kumar

Medically Reviewed By

Tarun Kumar, MPharm — Superintendent Pharmacist

GPhC No. 2233073 · Cured Health Ltd · Last reviewed: 21 July 2026

GPhC Verified

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